bubble_chart Synergistic tendency
The combination of these substances attenuates some of their effects and increases others.
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error_outline Estimated risk
The combination of these substances does not significantly increase their risks compared to independent use.
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flare About effects
It seems established that GHB has a two-phase effect: sedative at high doses, then stimulant in a second phase or at low doses. Its interactions therefore depend on both dosage and temporality. This particularity is documented in this small study, and in secondary sources such as PNWiki and this topic.
As the PsychonautWiki article summarizes, the effects of GHB may change drastically in function of dosage, and time. At high doses, it is sedative at the peak of the trip and stimulating at the end of it; in small doses, it is simply stimulating. Its synergies with other substances thus depend on these parameters.
GHB and MDMA both have in common their empathogenic, euphoric and disinhibiting effects. According to this meta study, episodic use of this combination leads to a reinforcement of the pro-social effects (empathy, chatter ...) while reducing the stimulation induced by MDMA.
menu_book About risks
GHB is a central nervous system depressant, which is easy to overdose with especially in combination with a stimulant that masks its effects.