bubble_chart Synergistic tendency
Increase
The effects of these substances are multiplied or greatly modified by their combination.
Reliability: hypothetical.
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error_outline Estimated risk
Unsafe
The combination of these substances presents non-negligible physical or mental risks.
Reliability: hypothetical.
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flare About effects
No additional information available.
menu_book About risks
Une étude infère que le tramadol couplé à des benzodiazépines pourrait être fatal, du fait de la potentialisation de leurs effets dépresseurs respectifs ainsi que d'une interaction au niveau de l'enzyme hépatique CYP3A.
Cependant des témoignages d'usage raisonné des deux substances en simultané ne montrent pas de problème particulier, faisant même remarquer les propriétés anticonvulsivantes de certaines diazépines telles que le diazepam ou le clonazepam.
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